Description

Methyl 2,3,5-Trifluoro-4-Piperidin-1-Ylbenzoate is a high-value fluorinated piperidine derivative, serving as a critical building block in modern synthetic chemistry. Its molecular architecture, featuring a trifluoromethyl benzoate ester linked to a piperidine moiety, makes it indispensable for introducing specific pharmacophores and modulating the physicochemical properties of target molecules. This advanced intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for complex ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers and liquid crystals where fluorinated aromatic systems are required.
• Chemical Biology Probes: Utilized to create fluorescent or bioactive probes for studying enzyme mechanisms and cellular pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions.

Basic Information

Product Name	Methyl 2,3,5-Trifluoro-4-Piperidin-1-Ylbenzoate
CAS No.	1858249-59-8
Molecular Formula	C13H14F3NO2
Molecular Weight	273.25 g/mol
Synonyms	Methyl 2,3,5-trifluoro-4-(piperidin-1-yl)benzoate; 4-Piperidin-1-yl-2,3,5-trifluorobenzoic Acid Methyl Ester; 2,3,5-Trifluoro-4-(1-piperidinyl)benzoic Acid Methyl Ester; 1-Piperidinebenzoic Acid, 2,3,5-trifluoro-4-, Methyl Ester; Methyl 2,3,5-Trifluoro-4-(1-piperidinyl)benzoate; Benzoic acid, 2,3,5-trifluoro-4-(1-piperidinyl)-, methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 2,3,5-Trifluoro-4-Piperidin-1-Ylbenzoate adheres to stringent internal quality standards, ensuring batch-to-batch consistency for research and development applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.