Description

2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Ol is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. This compound is valued for its unique pyridine-boronic ester structure, which is critical for facilitating key cross-coupling reactions like the Suzuki-Miyaura reaction. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the efficient synthesis of complex molecules and active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drug candidates targeting CNS disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling Reagent: The pinacol boronate ester functional group enables efficient carbon-carbon bond formation with aryl/heteroaryl halides, essential for constructing biaryl and heterobiaryl scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific pyridine-based architectures.
• Material Science & OLED Development: Serves as a building block for creating organic electronic materials, including ligands for metal-organic frameworks (MOFs) and emissive layers in organic light-emitting diodes (OLEDs).
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed in the modular synthesis of bifunctional molecules for targeted protein degradation research.
• Ligand Synthesis for Catalysis: Useful for preparing sophisticated pyridine-containing ligands used in asymmetric catalysis and transition metal complexes.

Basic Information

Item	Details
Product Name	2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Ol
CAS No.	1857348-99-2
Molecular Formula	C12H18BNO4
Molecular Weight	251.09 g/mol
Synonyms	3-Hydroxy-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methoxypyridin-3-ol; 2-Methoxy-5-(pinacolatoboryl)pyridin-3-ol; 3-Hydroxy-2-methoxy-5-pyridineboronic acid pinacol ester; 5-Borono-2-methoxypyridin-3-ol pinacol ester; Pyridine-3-ol, 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our 2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive coupling reactions. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.