Description

5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-1H-Inden-2-Ol CAS NO 1857348-77-6 is a high-value, functionalized indane derivative containing a pinacol boronate ester group. This compound serves as a critical advanced pharmaceutical intermediate (API) and versatile Suzuki-Miyaura cross-coupling building block for constructing complex organic molecules. It is essential for research and development chemists in the pharmaceutical, agrochemical, and materials science industries who require precise, high-purity boronic ester reagents for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the formation of carbon-carbon bonds in medicinal chemistry and materials research, offering excellent functional group tolerance.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with complex molecular architectures.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Organic Electronic Materials: A potential monomer or intermediate in the synthesis of conjugated polymers and organic semiconductors for OLEDs and photovoltaics.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein functions.

Basic Information

Product Name	5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-1H-Inden-2-Ol
CAS No.	1857348-77-6
Molecular Formula	C15H21BO3
Molecular Weight	260.14 g/mol
Synonyms	2,3-Dihydro-1H-inden-2-ol, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 5-(Pinacolatoboryl)-2,3-dihydro-1H-inden-2-ol; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indan-2-ol; 2-Hydroxyindane-5-boronic acid pinacol ester; Indan-2-ol, 5-(pinacolatoboryl)-; 1857348-77-6; 5-(Pinacolboron)indan-2-ol
EINECS	Contact for details

Quality Control

Our production of 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-1H-Inden-2-Ol adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.