Description

(3-Methyl-1-(Tetrahydro-2H-Pyran-4-Yl)-1H-Pyrazol-4-Yl)Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate belonging to the class of protected boronic acid derivatives. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions like the Suzuki-Miyaura reaction to construct complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the formation of carbon-carbon bonds between aryl/heteroaryl halides and boronic esters under palladium catalysis.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and library synthesis to explore new chemical space and develop candidate drug molecules.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides.
• Material Science: Potential use in the synthesis of organic electronic materials and functional polymers.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services.

Basic Information

Product Name	(3-Methyl-1-(Tetrahydro-2H-Pyran-4-Yl)-1H-Pyrazol-4-Yl)Boronic Acid Pinacol Ester
CAS No.	1853186-01-2
Molecular Formula	C15H25BN2O3
Molecular Weight	292.19 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole; 1-(Oxan-4-yl)-3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; (3-Methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)boronic acid pinacol ester; 3-Methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-boronic acid pinacol ester; 1-(Tetrahydro-2H-pyran-4-yl)-3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; THP-protected pyrazole boronic ester; CAS 1853186-01-2
EINECS	Contact for details

Quality Control

Our (3-Methyl-1-(Tetrahydro-2H-Pyran-4-Yl)-1H-Pyrazol-4-Yl)Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee consistency and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) and at temperatures between 2°C and 8°C for long-term stability. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.