Description

Trifluoroacetic Acid CAS NO 1844898-10-7 is a specialized fluorinated organic compound characterized as a strong acid and highly volatile solvent. Its unique combination of acidity and volatility makes it an indispensable reagent for advanced chemical synthesis and purification processes. This high-purity material is essential for industries requiring precise and powerful acidic conditions, including pharmaceutical manufacturing, agrochemical development, and materials science research.

Application

• Pharmaceutical Synthesis: A key reagent and protecting group removal agent (e.g., for Boc and t-butyl ester deprotection) in the production of active pharmaceutical ingredients (APIs) and peptides.
• Analytical Chemistry: Used as a volatile ion-pairing agent and mobile phase modifier in High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Spectrometry (LC-MS) for the separation of complex biomolecules.
• Organic Synthesis & Catalysis: Serves as a potent acid catalyst and solvent in various fluorination reactions, esterifications, and rearrangements.
• Polymer & Materials Science: Employed in the synthesis and processing of specialty polymers, including fluoropolymers, and as an etching agent in microfabrication.
• Agrochemical Intermediates: Used in the synthesis of advanced herbicides, pesticides, and other fluorinated agrochemical compounds.
• Peptide & Protein Chemistry: Critical for the cleavage of peptides from solid-phase resins and for the purification of synthetic peptides.

Basic Information

Product Name	Trifluoroacetic Acid
CAS No.	1844898-10-7
Molecular Formula	C2HF3O2
Molecular Weight	114.02 g/mol
Synonyms	Trifluoroethanoic Acid; Perfluoroacetic Acid; TFA; 2,2,2-Trifluoroacetic Acid; Acetic Acid, Trifluoro-; CF3COOH; Perfluoroacetic Acid; Kyselina Trifluoroctova
EINECS	Contact for details

Quality Control

Our Trifluoroacetic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for demanding applications. Production adheres to current Good Manufacturing Practices (cGMP) where applicable. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles, verified by advanced analytical techniques including GC, HPLC, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile and corrosive nature, containers must be kept upright and sealed when not in use. Recommended storage temperature is 2-8°C (refrigerated) for extended stability, though short-term storage at 15-25°C is acceptable.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms
Assay (GC)	≥ 99.5%
Water Content (Karl Fischer)	≤ 0.05%
Residue on Evaporation	≤ 0.005%
Chloride (Cl)	≤ 10 ppm
Sulfate (SO4)	≤ 10 ppm
Heavy Metals (as Pb)	≤ 5 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.