Description

n-Boc-8-Hydroxy-2,3,4,5-Tetrahydrobenzo[F][1,4]Oxazepine-7-Carbaldehyde is a high-purity, advanced pharmaceutical intermediate featuring a protected hydroxyl group and a reactive aldehyde functionality. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex heterocyclic scaffolds. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers in the synthesis of novel therapeutic agents, particularly within central nervous system (CNS) and oncology drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel benzoxazepine-based drug candidates.
• Medicinal Chemistry R&D: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degraders.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific synthesis projects.
• Academic Research: Used in university and institutional labs for exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	n-Boc-8-Hydroxy-2,3,4,5-Tetrahydrobenzo[F][1,4]Oxazepine-7-Carbaldehyde
CAS No.	1823551-73-0
Molecular Formula	C₁₆H₂₁NO₅
Molecular Weight	307.34 g/mol
Synonyms	tert-Butyl 8-hydroxy-7-formyl-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine-6(7H)-carboxylate; 8-Hydroxy-6-[(2-methylpropan-2-yl)oxycarbonyl]-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine-7-carbaldehyde; 7-Carbaldehyde-n-Boc-8-hydroxy-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine; Boc-Protected 8-Hydroxybenzooxazepine Carbaldehyde; 1823551-73-0; Benzo[f][1,4]oxazepine-7-carbaldehyde, 2,3,4,5-tetrahydro-8-hydroxy-6-[[(1,1-dimethylethoxy)carbonyl]-; 6-(tert-Butoxycarbonyl)-8-hydroxy-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine-7-carbaldehyde
EINECS	Contact for details

Quality Control

Our n-Boc-8-Hydroxy-2,3,4,5-Tetrahydrobenzo[F][1,4]Oxazepine-7-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and cGMP-grade requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.