Description

1-(4-Iodo-3-Trifluoromethyl-Phenyl)-Ethanone is a high-value, multi-functional aromatic ketone building block characterized by its iodine and trifluoromethyl substituents. This compound is essential for facilitating advanced cross-coupling reactions and introducing fluorinated motifs, which are critical for modulating the physicochemical properties of target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions for constructing complex biaryl structures in drug discovery.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a building block for organic semiconductors, liquid crystals, and advanced polymers requiring specific electronic properties.
• Fluorine Chemistry: An important reagent for introducing the pharmacologically privileged trifluoromethyl group into target molecules via further functionalization.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for imaging and diagnostic applications.

Basic Information

Product Name	1-(4-Iodo-3-Trifluoromethyl-Phenyl)-Ethanone
CAS No.	1823318-98-4
Molecular Formula	C9H6F3IO
Molecular Weight	314.05 g/mol
Synonyms	4'-Iodo-3'-(trifluoromethyl)acetophenone; 1-[4-Iodo-3-(trifluoromethyl)phenyl]ethanone; 4-Iodo-α,α,α-trifluoro-m-acetophenone; 4-Iodo-3-trifluoromethylacetophenone; 1-Acetyl-4-iodo-3-(trifluoromethyl)benzene; m-Trifluoromethyl-p-iodoacetophenone
EINECS	Contact for details

Quality Control

Our 1-(4-Iodo-3-Trifluoromethyl-Phenyl)-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere for long-term stability. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.