Description

Benzene, 1-Bromo-3-Fluoro-4-Methoxy-2-(Methylthio)- is a high-value, multi-functionalized aromatic building block designed for advanced synthetic chemistry. This compound matters because its unique combination of bromo, fluoro, methoxy, and methylthio substituents offers versatile reactivity for constructing complex molecules with precise electronic and steric properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in drug discovery, material science, and the synthesis of specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated aromatic cores for bioactivity or as a handle for further functionalization.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine atom can enhance metabolic stability and bioavailability.
• Material Science Research: Serves as a monomer or building block for developing advanced polymers, liquid crystals, or organic electronic materials due to its electron-rich and modifiable structure.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to form complex biaryl systems.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for catalysis, where the sulfur and oxygen donors can coordinate to various metals.
• Fluorine Chemistry Studies: Acts as a valuable model compound in medicinal chemistry for studying the effects of fluorine substitution on molecular properties.

Basic Information

Product Name	Benzene, 1-Bromo-3-Fluoro-4-Methoxy-2-(Methylthio)-
CAS No.	1822822-76-3
Molecular Formula	C8H8BrFO1S1
Molecular Weight	251.12 g/mol
Synonyms	1-Bromo-3-fluoro-4-methoxy-2-(methylthio)benzene; 2-Bromo-6-fluoro-3-methoxybenzenethiol, methyl ether; 3-Bromo-1-fluoro-2-methoxy-6-(methylthio)benzene; 4-Bromo-2-fluoro-5-methoxy-1-(methylthio)benzene; Benzene, 1-bromo-3-fluoro-4-methoxy-2-(methylthio)-; (3-Bromo-6-fluoro-2-methoxyphenyl)(methyl)sulfane
EINECS	Contact for details

Quality Control

Our Benzene, 1-Bromo-3-Fluoro-4-Methoxy-2-(Methylthio)- is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality systems are designed to support cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. Keep away from strong oxidizing agents and bases. The compound may be light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.