Description

5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethyl)-1H-Indazole is a high-value, multi-functional chemical building block designed for advanced synthetic chemistry. This compound is essential for facilitating key carbon-carbon bond-forming reactions, enabling the efficient synthesis of complex molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting kinase inhibition and other therapeutic areas where the indazole and trifluoromethyl motifs are pharmacologically relevant.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester reagent for palladium-catalyzed cross-coupling, enabling the efficient introduction of the 3-(trifluoromethyl)-1H-indazole moiety into complex molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the biological activity often associated with fluorinated heterocycles.
• Material Science & OLED Development: Acts as a building block for creating novel organic semiconductors, light-emitting materials, and other advanced functional materials.
• Chemical Biology & Probe Synthesis: Utilized in the creation of molecular probes and labeled compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical manufacturers for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethyl)-1H-Indazole
CAS No.	1821029-13-3
Molecular Formula	C₁₄H₁₆BF₃N₂O₂
Molecular Weight	312.10 g/mol
Synonyms	3-(Trifluoromethyl)-1H-indazole-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)-1H-indazole; 3-Trifluoromethyl-1H-indazole-5-boronic acid pinacol ester; 1H-Indazole-5-boronic acid, 3-(trifluoromethyl)-, 1,1-dimethylethyl ester; Pinacol 3-(trifluoromethyl)-1H-indazole-5-boronate; 5-Borono-3-(trifluoromethyl)-1H-indazole pinacol ester
EINECS	Contact for details

Quality Control

Our 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethyl)-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.