Description

Methyl 5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Benzofuran-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a benzofuran core and a pinacol boronate ester functional group. This compound is a critical building block in modern synthetic chemistry, enabling efficient cross-coupling reactions for the construction of complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic ester reagent for the palladium-catalyzed formation of carbon-carbon bonds, essential for constructing biaryl and heterobiaryl structures in drug discovery.
• Pharmaceutical Intermediate: Used in the research and development of new active pharmaceutical ingredients (APIs), particularly those containing benzofuran scaffolds with potential biological activity.
• Agrochemical Synthesis: Employed in the creation of novel herbicides, fungicides, and insecticides that require specific aromatic and heteroaromatic architectures.
• Material Science Research: Acts as a precursor for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where precise molecular engineering is required.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and labeled compounds for biochemical assays and diagnostic research.
• Process Chemistry & Scale-up: Provides a reliable and consistent starting material for the optimization and commercial-scale production of fine chemicals.

Basic Information

Product Name	Methyl 5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Benzofuran-2-Carboxylate
CAS No.	1820715-36-3
Molecular Formula	C16H21BO5
Molecular Weight	304.15 g/mol
Synonyms	Methyl 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-2-carboxylate; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzofuran-2-carboxylic acid methyl ester; 2-Benzofurancarboxylic acid, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; Methyl 5-(pinacolatoboryl)benzofuran-2-carboxylate; 5-Pinacolatoboryl-2-benzofurancarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Benzofuran-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and GC/MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.