Description

2-Isopropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is specifically designed for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for creating complex carbon-carbon bonds. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-quality boronic ester reagents for drug discovery and development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for novel small-molecule drugs.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical organoboron reagent for constructing biaryl and heterobiaryl structures in medicinal chemistry.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides requiring specific pyrimidine-based scaffolds.
• Materials Science: A precursor for creating organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and tool compounds for target identification and validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and scale-up projects.

Basic Information

Product Name	2-Isopropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine
CAS No.	1820679-54-6
Molecular Formula	C13H21BN2O2
Molecular Weight	248.13 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(propan-2-yl)pyrimidine; 2-Isopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-(Propan-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-Isopropylpyrimidine-5-boronic acid pinacol ester; Pyrimidine-5-boronic acid, 2-(1-methylethyl)-, 1,1,1',1'-tetramethyl-2,2'-bi[1,3,2]dioxaborolane-4,4'-diyl ester; 1820679-54-6
EINECS	Contact for details

Quality Control

Every batch of 2-Isopropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.