Description

3-[(4-Chlorophenyl)Sulfonyl]Azetidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique azetidine scaffold functionalized with a chlorophenylsulfonyl group. This compound is of significant value in modern medicinal chemistry for the synthesis of novel bioactive molecules, particularly as a key building block in drug discovery programs. It is primarily sought after by research institutions and pharmaceutical companies developing new therapeutic agents, especially in areas targeting central nervous system disorders and metabolic diseases.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel small-molecule drug candidates, particularly for neurological and metabolic targets.
• Protease Inhibitor Research: Used in the development of protease inhibitors due to the sulfonyl group's ability to act as a key pharmacophore.
• Kinase Inhibitor Scaffold: Serves as a core scaffold for designing and synthesizing selective kinase inhibitors for oncology research.
• Chemical Biology Probes: Employed in the creation of chemical probes to study enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Used in route scouting and process optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis services catering to specific client requirements in drug development.

Basic Information

Product Name	3-[(4-Chlorophenyl)Sulfonyl]Azetidine Hydrochloride
CAS No.	1820665-00-6
Molecular Formula	C9H11Cl2NO2S
Molecular Weight	276.16 g/mol
Synonyms	3-[(4-Chlorophenyl)sulfonyl]azetidine hydrochloride; 1-(4-Chlorobenzenesulfonyl)azetidine hydrochloride; Azetidine, 3-[(4-chlorophenyl)sulfonyl]-, hydrochloride; 3-(4-Chlorophenylsulfonyl)azetidine HCl; 4-Chloro-N-(azetidin-3-ylsulfonyl)aniline hydrochloride (tautomeric form); A-443654 (related research code); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 3-[(4-Chlorophenyl)Sulfonyl]Azetidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing specifications for assay, related substances, residual solvents, and other critical parameters is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.