Description

(R)-4-(2-Hydroxyethyl)-2,2-Diisopropyl-1,3-Dioxolane is a high-purity chiral building block and protected intermediate of significant value in advanced organic synthesis. This compound matters because it provides a stereochemically defined scaffold for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other specialty chemicals.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key building block for the development of enantiomerically pure drugs, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Active Ingredient Precursor: Used in the research and production of advanced, stereoselective pesticides and herbicides.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical and Flavor/Fragrance Intermediate: Employed in the synthesis of complex natural products and specialty aroma chemicals where specific stereochemistry is required.
• Academic and Industrial R&D: A valuable tool for methodological studies in organic chemistry, including new reaction development and stereoselective transformation research.

Basic Information

Product Name	(R)-4-(2-Hydroxyethyl)-2,2-Diisopropyl-1,3-Dioxolane
CAS No.	1820574-15-9
Molecular Formula	C11H22O3
Molecular Weight	202.29 g/mol
Synonyms	(R)-2,2-Diisopropyl-4-(2-hydroxyethyl)-1,3-dioxolane; (4R)-4-(2-Hydroxyethyl)-2,2-di(propan-2-yl)-1,3-dioxolane; (R)-1,3-Dioxolane-4-ethanol, 2,2-bis(1-methylethyl)-; (R)-Glycerol Acetonide; (R)-Isopropylidene Glycerol; (R)-Solketal; (R)-2,2-Dimethyl-4-(hydroxymethyl)-1,3-dioxolane (related structure); (R)-Acetonide of Glycerol
EINECS	Contact for details

Quality Control

Our (R)-4-(2-Hydroxyethyl)-2,2-Diisopropyl-1,3-Dioxolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC and NMR, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere such as nitrogen to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.