Description

1-[3-Methyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclopropane-1-Carbonitrile is a high-value, advanced pharmaceutical intermediate featuring a unique cyclopropane-carbonitrile core linked to a protected boronic ester. This compound is specifically engineered for use in modern synthetic methodologies, particularly Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is an essential building block for research and development chemists in the pharmaceutical, agrochemical, and material science industries seeking to introduce functionalized cyclopropane motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring a sterically constrained cyclopropane ring for biological activity or metabolic stability.
• Suzuki-Miyaura Cross-Coupling Reagent: The tetramethyl-1,3,2-dioxaborolane (pinacol boronic ester) protecting group makes this compound an air-stable, highly effective coupling partner for forming carbon-carbon bonds with aryl/vinyl halides under palladium catalysis.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the cyclopropane unit can enhance potency and environmental profile.
• Material Science & OLED Development: Serves as a building block for creating organic electronic materials, such as charge-transport layers or emitters in organic light-emitting diodes (OLEDs).
• Ligand & Catalyst Development: The nitrile and boronic ester functionalities provide handles for further chemical modification to create novel chiral ligands or organocatalysts.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	1-[3-Methyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclopropane-1-Carbonitrile
CAS No.	1818380-84-5
Molecular Formula	C17H22BNO2
Molecular Weight	283.18 g/mol
Synonyms	1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methylphenyl]cyclopropanecarbonitrile; 1-[3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropanecarbonitrile; (3-Methyl-4-(1-cyanocyclopropyl)phenyl)boronic acid pinacol ester; 4-(1-Cyanocyclopropyl)-2-methylphenylboronic acid pinacol ester; CAS 1818380-84-5
EINECS	Contact for details

Quality Control

Our production of 1-[3-Methyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclopropane-1-Carbonitrile adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, identity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.