Description

T-Butoxycarbonyl-Peg2-Sulfonic Acid is a specialized bifunctional organic compound that serves as a versatile building block in advanced chemical synthesis. Its molecular architecture, featuring a tert-butoxycarbonyl (Boc) protecting group, a polyethylene glycol (PEG) spacer, and a sulfonic acid moiety, makes it a critical reagent for introducing solubility-enhancing and anionic functional groups. This product is essential for researchers and process chemists in the pharmaceutical and bioconjugation sectors who require high-purity intermediates for developing new therapeutic agents and diagnostic tools.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in modifying peptides and small molecules to improve solubility and pharmacokinetic properties.
• Bioconjugation Reagent: Used to link active molecules (e.g., drugs, dyes, targeting ligands) to proteins, antibodies, or nanoparticles, facilitating the creation of antibody-drug conjugates (ADCs) and other targeted therapies.
• Polymer Modification: Employed to introduce sulfonate groups and PEG chains into polymers, enhancing hydrophilicity, biocompatibility, and anti-fouling characteristics for biomedical applications.
• Linker Chemistry: Serves as a cleavable or stable linker in solid-phase peptide synthesis (SPPS) and combinatorial chemistry, enabling the controlled assembly of complex molecules.
• Surface Functionalization: Utilized to modify material surfaces (e.g., gold, silica) with PEG-sulfonate layers to create non-fouling, hydrophilic coatings for biosensors and implants.
• Catalyst and Ligand Synthesis: Acts as a precursor for creating water-soluble ligands and organocatalysts used in green chemistry and aqueous-phase reactions.

Basic Information

Product Name	T-Butoxycarbonyl-Peg2-Sulfonic Acid
CAS No.	1817735-40-2
Molecular Formula	C13H27NO8S
Molecular Weight	357.42 g/mol
Synonyms	Boc-PEG2-Sulfonic Acid; 2-[2-(2-{[(tert-Butoxy)carbonyl]amino}ethoxy)ethoxy]ethanesulfonic Acid; tert-Butyl N-[2-[2-(2-sulfoethoxy)ethoxy]ethyl]carbamate; Boc-NH-PEG2-SO3H; Boc-Amino-PEG2-Sulfonic Acid; (tert-Butoxycarbonylamino)polyethylene glycol sulfonic acid; PEG2-Boc-Sulfonic Acid
EINECS	Contact for details

Quality Control

Every batch of T-Butoxycarbonyl-Peg2-Sulfonic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay, impurity profile, and residual solvents. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.