Description

Carboxy-Peg5-Sulfonic Acid is a high-purity, bifunctional polyethylene glycol (PEG) derivative featuring a carboxylic acid and a sulfonic acid group, separated by a pentaethylene glycol spacer. This unique structure makes it a valuable heterobifunctional linker and hydrophilic modifier for bioconjugation, surface functionalization, and the synthesis of advanced materials. It is particularly essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise, water-soluble spacers to enhance the solubility and pharmacokinetic properties of therapeutic agents, diagnostic probes, and biomaterials. The compound's dual functionality allows for sequential and site-specific coupling strategies under mild aqueous conditions.

Application

• Bioconjugation Linker: For coupling peptides, proteins, or antibodies to nanoparticles, surfaces, or other biomolecules via its carboxylic acid and sulfonic acid groups.
• PEGylation Reagent: To introduce hydrophilic PEG chains and negative charge (from sulfonic acid) onto drug molecules or surfaces, improving solubility, stability, and circulation time.
• Surface Modification: Functionalization of gold nanoparticles, quantum dots, and other nanomaterials to create stable, biocompatible, and charged interfaces.
• Hydrogel Synthesis: As a cross-linking agent or functional monomer in the preparation of smart, charged hydrogels for drug delivery and tissue engineering.
• Chromatography Media: Modification of stationary phases to introduce hydrophilic and ion-exchange properties for improved separation of biomolecules.
• Diagnostic Probe Development: Building block for synthesizing contrast agents or fluorescent probes with enhanced water solubility and targeting capabilities.
• Polymer Chemistry: Monomer or chain extender for creating functional, water-soluble copolymers with specific acid groups.

Basic Information

Item	Detail
Product Name	Carboxy-Peg5-Sulfonic Acid
CAS No.	1817735-38-8
Molecular Formula	C17H32O12S
Molecular Weight	460.5 g/mol
Synonyms	5-Carboxy-3,6,9,12,15-pentaoxa-18-thiaoctadecanoic acid; HOOC-PEG5-SO3H; Carboxy-Pentaethylene glycol-Sulfonic Acid; α-Carboxy-ω-sulfonic acid-PEG5; 3,6,9,12,15-Pentaoxaoctadecane-1,18-dioic acid, 18-sulfo-; PEG5 dicarboxylic sulfonic acid; 2-[2-[2-[2-[2-(Sulfooxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
EINECS	Contact for details

Quality Control

Our Carboxy-Peg5-Sulfonic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and bioconjugation applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.