Description

Boc-n-Amido-Peg3-Sulfonic Acid is a specialized bifunctional PEG linker featuring a tert-butyloxycarbonyl (Boc) protected amine and a terminal sulfonic acid group. This compound is engineered to facilitate the synthesis of complex molecules, offering a hydrophilic polyethylene glycol (PEG) spacer that enhances solubility and modulates pharmacokinetic properties. It is a critical intermediate for researchers and manufacturers in pharmaceutical development, bioconjugation, and proteomics, enabling the creation of targeted drug conjugates, diagnostic agents, and advanced biomaterials.

Application

• Bioconjugation and ADC Development: Used as a key linker for attaching cytotoxic drugs to antibodies or targeting ligands in Antibody-Drug Conjugate (ADC) synthesis.
• Peptide and Protein Modification: Serves as a hydrophilic spacer to introduce sulfonic acid groups or protected amines into peptides and proteins, improving solubility and stability.
• Polymer and Material Science: Acts as a functional monomer or cross-linker for creating smart hydrogels, surface coatings, and drug delivery systems with tailored properties.
• Diagnostic Reagent Synthesis: Employed in the preparation of contrast agents, fluorescent probes, and other diagnostic tools where a water-soluble, functionalizable linker is required.
• Chemical Biology and Proteomics: Utilized as a building block for activity-based probes and affinity tags to study protein function and interactions.
• Solubility Enhancer for APIs: The PEG spacer can be incorporated into Active Pharmaceutical Ingredients (APIs) to significantly enhance aqueous solubility and bioavailability.

Basic Information

Product Name	Boc-n-Amido-Peg3-Sulfonic Acid
CAS No.	1817735-32-2
Molecular Formula	C16H31NO9S
Molecular Weight	413.48 g/mol
Synonyms	1-(1,3-Dioxoisoindolin-2-yl)-3,6,9-trioxa-12-azatetradecane-14-sulfonic acid, 12-Boc; 2,5,8,11-Tetraoxatetradecan-14-oic acid, 13-[[(1,1-dimethylethoxy)carbonyl]amino]-, 14-sulfonic acid; Boc-NH-PEG3-Sulfonic Acid; Boc-Amine-PEG3-SO3H; tert-Butyl (14-sulfo-3,6,9-trioxa-12-azatetradecyl)carbamate; N-Boc-3,6,9-trioxa-12-azatetradecane-14-sulfonic acid; Boc-protected PEG3 sulfonic acid
EINECS	Contact for details

Quality Control

Our Boc-n-Amido-Peg3-Sulfonic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive). For long-term stability, store desiccated at -20°C. Under these conditions, the product is typically stable for at least 24 months. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.