Description

Propargyl-Peg4-Sulfonic Acid is a specialized bifunctional linker molecule featuring a terminal propargyl group and a sulfonic acid moiety, connected by a tetraethylene glycol (PEG4) spacer. This unique structure makes it a critical reagent for click chemistry and bioconjugation strategies, offering both water solubility from the PEG-sulfonate chain and a reactive handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is primarily utilized by researchers and manufacturers in pharmaceutical development, proteomics, and materials science for the precise modification and functionalization of biomolecules, polymers, and surfaces.

Application

• Bioconjugation & Protein Labeling: Acts as a heterobifunctional crosslinker for attaching azide-modified dyes, drugs, or probes to biomolecules via click chemistry.
• ADC (Antibody-Drug Conjugate) Development: Serves as a hydrophilic linker to conjugate cytotoxic payloads to antibodies, improving solubility and pharmacokinetics.
• Polymer & Surface Functionalization: Used to introduce sulfonate groups and click-reactive sites onto polymers, nanoparticles, or biosensor surfaces to enhance hydrophilicity and enable further modification.
• Proteomics Research: Employed in activity-based protein profiling (ABPP) and chemoproteomics for labeling and enriching target enzymes.
• Hydrogel Synthesis: Incorporated as a crosslinking agent or functional monomer to create clickable, sulfonated hydrogels for biomedical applications.
• Ligand & Affinity Reagent Synthesis: Facilitates the construction of sulfonated small-molecule ligands or affinity tags for studying protein-ligand interactions.

Basic Information

Product Name	Propargyl-Peg4-Sulfonic Acid
CAS No.	1817735-29-7
Molecular Formula	C₁₅H₂₈O₉S
Molecular Weight	408.44 g/mol
Synonyms	Propargyl-PEG4-sulfonic acid; 2,5,8,11-Tetraoxatetradec-13-yne-14-sulfonic acid; 3-((2-(2-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)ethoxy)ethyl)sulfonyl)propanoic acid (alternative IUPAC); Propargyl tetraethylene glycol sulfonate; Propargyl-PEG4-SO3H; Alkyne-PEG4-sulfonic acid; Click chemistry sulfonic acid linker; PEG4-Alkyne-Sulfonate
EINECS	Contact for details

Quality Control

Our Propargyl-Peg4-Sulfonic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support development and production needs across various standards, including cGMP for advanced therapeutic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.