Description

T-Butoxycarbonyl-Peg4-Sulfonic Acid is a high-purity, functionalized PEG linker featuring a Boc-protected amine and a terminal sulfonic acid group. This bifunctional compound is engineered to provide a versatile and water-soluble spacer for bioconjugation and pharmaceutical development, enabling precise molecular assembly. It is primarily utilized by researchers and manufacturers in the fields of proteomics, antibody-drug conjugate (ADC) development, and peptide synthesis where controlled linkage and enhanced solubility are critical.

Application

• Bioconjugation Reagent: Serves as a heterobifunctional crosslinker for coupling biomolecules like proteins, peptides, or antibodies to drugs, surfaces, or other functional groups.
• Antibody-Drug Conjugate (ADC) Linker: Used in the design and synthesis of ADCs, where its hydrophilic PEG spacer improves solubility and pharmacokinetics of the conjugate.
• Peptide Synthesis Intermediate: Acts as a key building block in solid-phase and solution-phase peptide synthesis, introducing sulfonic acid functionality or serving as a protected handle.
• Prodrug Development: Employed to create water-soluble prodrugs by conjugating hydrophobic active pharmaceutical ingredients (APIs) via the cleavable Boc and sulfonate groups.
• Surface Functionalization: Used to modify materials and nanoparticles with sulfonic acid groups for improved biocompatibility or specific binding characteristics.
• Polymer Chemistry: Functions as a monomer or modifier for creating functional polymers with tailored acid and solubility properties.

Basic Information

Product Name	T-Butoxycarbonyl-Peg4-Sulfonic Acid
CAS No.	1817735-26-4
Molecular Formula	C17H33NO11S
Molecular Weight	459.51 g/mol
Synonyms	Boc-NH-PEG4-Sulfonic Acid; tert-Butyl (17-sulfo-3,6,9,12-tetraoxa-16-azaheptadecyl)carbamate; 2,5,8,11-Tetraoxatetradecane-14-sulfonic acid, 14-[[(1,1-dimethylethoxy)carbonyl]amino]-; Boc-Amino-PEG4-Sulfonic Acid; Boc-PEG4-SO3H; N-Boc-1-amino-3,6,9,12-tetraoxapentadecane-15-sulfonic Acid; 15-((tert-Butoxycarbonyl)amino)-3,6,9,12-tetraoxapentadecane-1-sulfonic Acid
EINECS	Contact for details

Quality Control

Our T-Butoxycarbonyl-Peg4-Sulfonic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.