Description

Carboxy-Peg4-Sulfonic Acid is a high-purity, bifunctional PEG linker featuring a carboxylic acid and a sulfonic acid group, separated by a tetraethylene glycol spacer. This unique structure makes it a critical intermediate for creating water-soluble, charged conjugates in advanced bioconjugation and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, diagnostics, and materials science who require precise, stable, and functional linkers for modifying peptides, proteins, and nanoparticles.

Application

• Bioconjugation Reagent: Used to introduce negative charge and hydrophilicity to peptides, proteins, and antibodies for improved solubility and pharmacokinetics.
• ADC (Antibody-Drug Conjugate) Linker: Serves as a functional spacer in the synthesis of next-generation ADCs, enabling controlled drug release profiles.
• Polymer Modification: A key monomer or modifier for synthesizing functionalized, water-soluble polymers and hydrogels with anionic character.
• Diagnostic Probe Synthesis: Facilitates the attachment of targeting ligands to imaging agents (e.g., fluorescent dyes, MRI contrast agents) while enhancing their aqueous compatibility.
• Surface Functionalization: Used to create charged, PEGylated surfaces on nanoparticles and medical devices to reduce non-specific binding and improve biocompatibility.
• Chemical Biology Tool: Employed in the development of activity-based probes and affinity tags for proteomics research.

Basic Information

Product Name	Carboxy-Peg4-Sulfonic Acid
CAS No.	1817735-25-3
Molecular Formula	C13H26O11S
Molecular Weight	390.41 g/mol
Synonyms	3,6,9,12-Tetraoxapentadecane-1,15-dioic acid, 15-sulfo-; 15-Sulfo-3,6,9,12-tetraoxapentadecanedioic acid; HOOC-PEG4-SO3H; Carboxy-Tetraethyleneglycol-Sulfonic Acid; 2-[2-[2-[2-(2-Carboxyethoxy)ethoxy]ethoxy]ethoxy]ethanesulfonic acid; PEG4-acid-sulfonic acid; 4,7,10,13-Tetraoxahexadecanedioic acid, 16-sulfo-; Sulfonated PEG4 diacid
EINECS	Contact for details

Quality Control

Our Carboxy-Peg4-Sulfonic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and titration for functional group quantification, to ensure compliance with exacting standards for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Assay (Titration)	95.0 - 105.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.