Description

cis-3-(4-(Trifluoromethyl)Phenyl)Cyclobutanamine is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclobutane core substituted with a trifluoromethylphenyl group. This compound is valued for its role in modulating the physicochemical and metabolic properties of active pharmaceutical ingredients (APIs), making it a critical building block in modern drug discovery. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas such as central nervous system (CNS) disorders, oncology, and inflammatory diseases.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of novel small-molecule drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical entities, leveraging the cyclobutane scaffold and fluorine substitution.
• Proteolysis Targeting Chimera (PROTAC) Linkers: Serves as a potential component in the design of bifunctional molecules for targeted protein degradation.
• Agrochemical Synthesis: Intermediate in the research and development of new generation pesticides and herbicides.
• Material Science: Building block for specialty polymers and advanced organic electronic materials.

Basic Information

Item	Detail
Product Name	cis-3-(4-(Trifluoromethyl)Phenyl)Cyclobutanamine
CAS No.	1812174-93-8
Molecular Formula	C11H12F3N
Molecular Weight	215.21 g/mol
Synonyms	cis-3-[4-(Trifluoromethyl)phenyl]cyclobutanamine; 3-(4-(Trifluoromethyl)phenyl)cyclobutan-1-amine (cis-); 1-Amino-3-[4-(trifluoromethyl)phenyl]cyclobutane (cis-); 4-(Trifluoromethyl)phenyl cyclobutanamine; (1s,3s)-3-(4-(Trifluoromethyl)phenyl)cyclobutan-1-amine; (1r,3r)-3-(4-(Trifluoromethyl)phenyl)cyclobutan-1-amine; BRN 8281615
EINECS	Contact for details

Quality Control

Every batch of cis-3-(4-(Trifluoromethyl)Phenyl)Cyclobutanamine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.