Description

1-(2,4-Dichlorophenyl)-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is a high-value, advanced pharmaceutical intermediate featuring a unique urea linker and a protected boronic acid ester functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules through versatile cross-coupling reactions. It is primarily needed by R&D scientists and process chemists in the pharmaceutical and agrochemical industries for developing new active ingredients, particularly in kinase inhibitor and targeted therapy programs.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester moiety serves as a crucial handle for palladium-catalyzed carbon-carbon bond formation, enabling the construction of complex biaryl structures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore new chemical space.
• Agrochemical Development: Intermediate for creating new active ingredients with potential herbicidal or fungicidal properties.
• Chemical Biology Probes: Building block for synthesizing molecular probes to study biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development-scale batches.

Basic Information

Product Name	1-(2,4-Dichlorophenyl)-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea
CAS No.	1809876-48-9
Molecular Formula	C19H20BCl2N2O3
Molecular Weight	421.09 g/mol
Synonyms	1-(2,4-Dichlorophenyl)-3-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; N-(2,4-Dichlorophenyl)-N'-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl 2,4-dichlorophenyl urea; Urea, N-(2,4-dichlorophenyl)-N'-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; Boric acid, cyclic ester with N-(2,4-dichlorophenyl)-N'-(3-hydroxyphenyl)urea
EINECS	Contact for details

Quality Control

Our 1-(2,4-Dichlorophenyl)-3-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements. We support development with GMP-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.