Description

1-Bromo-3-Chloro-4-Methoxy-5-(Trifluoromethyl)Benzene is a high-value, multi-functional halogenated aromatic building block, distinguished by its unique substitution pattern. Its core value proposition lies in enabling the synthesis of complex molecules for advanced material science and life sciences, where precise structural control is paramount. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogen and trifluoromethyl motifs into their target structures. The CAS number for this compound is 1809161-58-7.

Application

This versatile intermediate serves as a critical precursor in several high-tech applications:

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology, where the trifluoromethyl group enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the halogen and methoxy groups for targeted biological activity and environmental selectivity.
• Liquid Crystal & OLED Materials: Serves as a core unit in the synthesis of advanced organic electronic materials, where its rigid, substituted benzene ring contributes to the desired molecular anisotropy and electronic properties for displays and lighting.
• Polymer & Resin Modifiers: Incorporated into polymer chains to impart specific characteristics such as flame retardancy, chemical resistance, or altered refractive index.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) due to the presence of bromo and chloro leaving groups, allowing for sequential, selective functionalization.
• Chemical Research & Development: A valuable tool for medicinal and synthetic chemists exploring new chemical spaces and developing novel synthetic methodologies.

Basic Information

Item	Details
Product Name	1-Bromo-3-Chloro-4-Methoxy-5-(Trifluoromethyl)Benzene
CAS No.	1809161-58-7
Molecular Formula	C8H5BrClF3O
Molecular Weight	289.48 g/mol
Synonyms	3-Bromo-5-Chloro-4-Methoxybenzotrifluoride; 5-Bromo-3-Chloro-4-Methoxybenzotrifluoride; 1-Bromo-3-chloro-4-methoxy-5-(trifluoromethyl)benzene; 4-Methoxy-3-bromo-5-chlorobenzotrifluoride; 2-Bromo-4-chloro-5-methoxy-α,α,α-trifluorotoluene; Benzene, 1-bromo-3-chloro-4-methoxy-5-(trifluoromethyl)-; BCMM-TFMB (common abbreviation)
EINECS	Contact for details

Quality Control

Our production of 1-Bromo-3-Chloro-4-Methoxy-5-(Trifluoromethyl)Benzene adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical specifications. Our quality system is designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 2°C and 25°C. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.