Description

Methyl Thiazole-2-Carboxylate-4-Boronic Acid Pinacol Ester is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel thiazole-containing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides containing the thiazole heterocycle.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLED emitters and charge transport layers.
• Chemical Biology Probes: Serves as a precursor for bioconjugation reagents and activity-based probes targeting specific enzymes.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries via parallel and combinatorial chemistry.
• Ligand and Catalyst Development: Used to prepare novel ligands for transition metal catalysis and organocatalysts.

Basic Information

Product Name	Methyl Thiazole-2-Carboxylate-4-Boronic Acid Pinacol Ester
CAS No.	1808928-32-6
Molecular Formula	C12H18BNO4S
Molecular Weight	283.15 g/mol
Synonyms	Methyl 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole-2-carboxylate; 2-Thiazolecarboxylic acid, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; Methyl 4-Borono-2-thiazolecarboxylate Pinacol Ester; 4-Borono-2-thiazolecarboxylic Acid Methyl Ester Pinacol Ester; MTCPE; Thiazole-4-boronic Acid Pinacol Ester, 2-Methoxycarbonyl-; CAS 1808928-32-6
EINECS	Contact for details

Quality Control

Our Methyl Thiazole-2-Carboxylate-4-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to prevent hydrolysis of the boronic ester.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.