Description

6-Amino-Spiro[3.3]heptane-2-carboxylic acid methyl ester hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is valued for its role in medicinal chemistry as a versatile building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disease research. It is primarily sought by R&D laboratories and pharmaceutical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component for constructing linkers or warheads in bifunctional degrader molecules.
• CNS Drug Discovery: Applied in the research and development of therapeutics targeting neurological disorders.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring high-fidelity spirocyclic chemistry.

Basic Information

Product Name	6-Amino-Spiro[3.3]heptane-2-Carboxylic Acid Methyl Ester Hydrochloride
CAS No.	1808249-67-3
Molecular Formula	C10H16ClNO2
Molecular Weight	217.69 g/mol
Synonyms	Methyl 6-amino-2-azaspiro[3.3]heptane-2-carboxylate hydrochloride; 2-Azaspiro[3.3]heptane-2-carboxylic acid, 6-amino-, methyl ester, hydrochloride; 6-Amino-2-azaspiro[3.3]heptane-2-carboxylic acid methyl ester HCl; Methyl 6-amino-2-azaspiro[3.3]heptane-2-carboxylate HCl; 6-Amino-spiro[3.3]heptane-2-carboxylic acid methyl ester hydrochloride; (6-Amino-2-azaspiro[3.3]hept-2-yl)methyl carboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our 6-Amino-Spiro[3.3]heptane-2-carboxylic acid methyl ester hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.