Description

Ald-Ph-Peg3-Nh-Boc is a specialized bifunctional PEG linker featuring an aldehyde group and a Boc-protected amine, connected by a triethylene glycol spacer. This compound is essential for creating stable, cleavable, and biocompatible conjugation bridges in advanced bioconjugation and drug delivery system development. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for antibody-drug conjugate (ADC) development, peptide modification, and surface functionalization of nanoparticles and biomaterials.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key component for constructing cleavable linkers, connecting cytotoxic payloads to monoclonal antibodies.
• Peptide and Protein Modification: Used for site-specific labeling, PEGylation, and cross-linking of biomolecules via its reactive aldehyde and amine groups.
• Surface Functionalization: Enables the covalent attachment of bioactive molecules to nanoparticles, microspheres, and biosensor surfaces.
• Polymer and Dendrimer Synthesis: Acts as a versatile building block for synthesizing functionalized polymers with tailored properties.
• Prodrug Development: Facilitates the design of prodrugs where the active pharmaceutical ingredient is released upon specific biological triggers.
• Biomaterial Engineering: Used to create hydrogels and other biomaterials with controlled degradation and cell-interactive properties.

Basic Information

Product Name	Ald-Ph-Peg3-Nh-Boc
CAS No.	1807540-87-9
Molecular Formula	C22H35NO7
Molecular Weight	425.52 g/mol
Synonyms	1. 4-Formylbenzyl-PEG3-NH-Boc 2. 4-((1,8-Dioxo-3,6,9-trioxa-2,10-diazadodecan-12-yl)oxy)methyl)benzaldehyde 3. Ald-Ph-PEG3-NHBoc 4. Boc-NH-PEG3-CH2-Ph-CHO 5. (Boc-amino)-PEG3-benzaldehyde 6. 4-[(3-{2-[2-(2-{[(tert-Butoxy)carbonyl]amino}ethoxy)ethoxy]ethoxy}methyl]benzaldehyde 7. Benzaldehyde, 4-[[3-[2-[2-(2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy)ethoxy]ethoxy]methyl]- 8. Boc-N-amido-PEG3-Ph-CHO
EINECS	Contact for details

Quality Control

Our Ald-Ph-Peg3-Nh-Boc is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural integrity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with research and cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC/MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.