Description

2-Chloro-3,4-Difluorobenzyl Chloride is a versatile and highly reactive benzyl halide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of halogen atoms, which enables selective functionalization for creating complex molecular architectures. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing difluorophenyl motifs.
• Agrochemical Synthesis: Building block for developing new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Liquid Crystal & OLED Materials: Used in the production of fluorinated aromatic compounds for electronic display and lighting applications.
• Polymer Modification: Serves as a functional monomer or cross-linking agent to introduce specific properties into polymer chains.
• Organic Synthesis Reagent: Employed in nucleophilic substitution reactions to introduce the benzyl chloride group into target molecules.
• Chemical Research & Development: A valuable tool for medicinal chemistry and material science research programs.

Basic Information

Product Name	2-Chloro-3,4-Difluorobenzyl Chloride
CAS No.	1807166-53-5
Molecular Formula	C7H4Cl2F2
Molecular Weight	197.01 g/mol
Synonyms	1-(Chloromethyl)-2-chloro-3,4-difluorobenzene; (2-Chloro-3,4-difluorophenyl)methyl chloride; 3,4-Difluoro-2-chlorobenzyl chloride; α,2-Dichloro-3,4-difluorotoluene; Benzene, 1-(chloromethyl)-2-chloro-3,4-difluoro-; 2-Chloro-3,4-difluorobenzylchloride
EINECS	Contact for details

Quality Control

Our 2-Chloro-3,4-Difluorobenzyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.