Description

3',4'-Dichloro-2'-Fluoroacetophenone is a high-purity fluorinated acetophenone derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate) and versatile building block in organic synthesis. Its precise molecular architecture, featuring strategically placed halogen atoms, enables the synthesis of complex molecules with targeted biological activity. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used as a building block for developing new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity imparted by the fluorine and chlorine substituents.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers and liquid crystals with specific optical or electronic properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Heck) and nucleophilic substitution reactions to construct complex, poly-substituted aromatic systems for various R&D applications.

Basic Information

Item	Details
Product Name	3',4'-Dichloro-2'-Fluoroacetophenone
CAS No.	1806354-87-9
Molecular Formula	C8H5Cl2FO
Molecular Weight	207.03 g/mol
Synonyms	1-(3,4-Dichloro-2-fluorophenyl)ethan-1-one; 3,4-Dichloro-2-fluoroacetophenone; 2-Fluoro-3,4-dichloroacetophenone; 3,4-Dichloro-2-fluorophenyl methyl ketone; 1-(3,4-Dichloro-2-fluorophenyl)ethanone; Acetophenone, 3',4'-dichloro-2'-fluoro-; 3,4-Dichloro-2-fluoro-1-acetylbenzene
EINECS	Contact for details

Quality Control

Our 3',4'-Dichloro-2'-Fluoroacetophenone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from HPLC, GC, NMR, and IR spectroscopy. Our quality commitment ensures the material meets the stringent requirements for use as a pharmaceutical intermediate and in other sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.