Description

Ethyl 3,5-Difluoro-4-Methylbenzoate is a high-purity fluorinated aromatic ester building block essential for advanced organic synthesis. This compound is valued for its role in introducing the difluoromethyl benzoate moiety, a key structural feature in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the difluoro and ester groups contribute to efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a building block for fluorinated components in liquid crystal displays (LCDs) due to its influence on polarity and mesomorphic properties.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Chemical Research & Development: A versatile reagent for exploring new fluorination methodologies and constructing complex aromatic scaffolds in academic and industrial labs.

Basic Information

Product Name	Ethyl 3,5-Difluoro-4-Methylbenzoate
CAS No.	1806321-00-5
Molecular Formula	C10H10F2O2
Molecular Weight	200.18 g/mol
Synonyms	Benzoic acid, 3,5-difluoro-4-methyl-, ethyl ester; 4-Methyl-3,5-difluorobenzoic acid ethyl ester; Ethyl 4-methyl-3,5-difluorobenzoate; 3,5-Difluoro-4-methylbenzoic acid ethyl ester; Ethyl 3,5-difluoro-p-toluate
EINECS	Contact for details

Quality Control

Every batch of Ethyl 3,5-Difluoro-4-Methylbenzoate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, and NMR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.