Description

2'-Bromo-4'-Chloro-5'-(Trifluoromethyl)Acetophenone is a high-purity, multi-functional halogenated acetophenone derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its value lies in the strategic placement of bromo, chloro, and trifluoromethyl substituents, which provide versatile reactive sites for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl group.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials with unique electronic or thermal properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands and catalysts for asymmetric synthesis and coupling reactions.
• Fluorine Chemistry Research: An important substrate for studying the introduction and transformation of fluorine-containing groups in organic molecules.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Item	Detail
Product Name	2'-Bromo-4'-Chloro-5'-(Trifluoromethyl)Acetophenone
CAS No.	1805584-92-2
Molecular Formula	C9H5BrClF3O
Molecular Weight	301.49 g/mol
Synonyms	1-(2-Bromo-4-chloro-5-(trifluoromethyl)phenyl)ethan-1-one; 2-Bromo-4-chloro-α,α,α-trifluoroacetophenone; 2-Bromo-4-chloro-5-trifluoromethylacetophenone; 2'-Bromo-4'-chloro-α,α,α-trifluoroacetophenone; 1-(2-Bromo-4-chloro-5-(trifluoromethyl)phenyl)ethanone; Acetophenone, 2'-bromo-4'-chloro-5'-(trifluoromethyl)-; BK-4C-5TFA
EINECS	Contact for details

Quality Control

Every batch of 2'-Bromo-4'-Chloro-5'-(Trifluoromethyl)Acetophenone is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure consistency and purity. Our standard grade meets a typical purity specification of ≥97% (by HPLC), with comprehensive control of related substances and residual solvents. A detailed Certificate of Analysis (COA) documenting identity, purity, and all critical parameters is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.