Description

1-(4-Bromo-5-Fluoro-2-Nitro-Phenyl)-Ethanone is a high-purity, multi-functional aromatic ketone building block designed for advanced synthetic chemistry. This compound is critical for researchers and manufacturers requiring precise, reliable intermediates for complex molecular assembly. It is primarily utilized in the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials, serving as a key precursor for introducing bromo, fluoro, and nitro functional groups into target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and pesticides, leveraging its halogenated nitroaromatic structure.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed in the creation of chemical probes and affinity tags for studying protein function and interaction.
• Dye & Pigment Intermediate: Acts as a starting material for synthesizing complex, high-performance colorants and imaging agents.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig amination due to the reactive bromo substituent.

Basic Information

Product Name	1-(4-Bromo-5-Fluoro-2-Nitro-Phenyl)-Ethanone
CAS No.	1805555-80-9
Molecular Formula	C8H5BrFNO3
Molecular Weight	262.04 g/mol
Synonyms	4'-Bromo-5'-fluoro-2'-nitroacetophenone; 1-Acetyl-4-bromo-5-fluoro-2-nitrobenzene; 2-Nitro-4-bromo-5-fluoroacetophenone; 4-Bromo-5-fluoro-2-nitroacetophenone; Ethanone, 1-(4-bromo-5-fluoro-2-nitrophenyl)-; (4-Bromo-5-fluoro-2-nitrophenyl)ethanone; 1-(4-Bromo-5-fluoro-2-nitrophenyl)ethan-1-one
EINECS	Contact for details

Quality Control

Our 1-(4-Bromo-5-Fluoro-2-Nitro-Phenyl)-Ethanone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical specifications. Our quality commitment supports applications requiring compliance with cGMP, ICH Q7, and other relevant pharmaceutical and chemical industry guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.