Description

2-Bromo-3,4-Difluorobenzyl Bromide is a versatile and highly reactive benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of halogen atoms, which enable precise functionalization and the construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, where it is used to develop new active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorine-containing drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to construct novel herbicide and pesticide molecules, where the difluoro and bromo substituents can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized phosphine or nitrogen-based ligands used in transition metal catalysis.
• Material Science Monomer: Employed in the synthesis of functionalized polymers and liquid crystals, where the benzyl bromide group allows for polymerization or attachment to surfaces.
• Chemical Biology Probes: Useful for the site-specific modification of proteins or biomolecules via alkylation reactions, aiding in drug discovery research.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.

Basic Information

Product Name	2-Bromo-3,4-Difluorobenzyl Bromide
CAS No.	1805523-88-9
Molecular Formula	C7H4Br2F2
Molecular Weight	285.91 g/mol
Synonyms	1-(Bromomethyl)-2-bromo-3,4-difluorobenzene; 3,4-Difluoro-2-bromobenzyl Bromide; (2-Bromo-3,4-difluorophenyl)methyl Bromide; α,2-Dibromo-3,4-difluorotoluene; Benzene, 1-(bromomethyl)-2-bromo-3,4-difluoro-; 2-Bromo-3,4-difluoro-α-bromotoluene
EINECS	Contact for details

Quality Control

Our 2-Bromo-3,4-Difluorobenzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.