Description

2-Bromo-3,5-Difluorobenzodifluoride is a high-value, multi-fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of fluorine atoms is crucial for modulating biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the difluoro and bromo substituents contribute to enhanced efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic cores in electronic materials, contributing to improved charge transport, thermal stability, and optical properties.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, enhancing their chemical resistance, surface properties, and durability.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to construct complex biaryl systems.
• Fluorinated Ligand Synthesis: Used in the preparation of specialized fluorinated ligands for catalysis and material science applications.

Basic Information

Product Name	2-Bromo-3,5-Difluorobenzodifluoride
CAS No.	1805422-87-0
Molecular Formula	C7H2BrF4
Molecular Weight	240.99 g/mol
Synonyms	1-Bromo-2,4-difluoro-5-(trifluoromethyl)benzene; 2,4-Difluoro-1-bromo-5-(trifluoromethyl)benzene; 2-Bromo-α,α,3,5-tetrafluorotoluene; 5-Bromo-2,4-difluorobenzotrifluoride; Benzene, 1-bromo-2,4-difluoro-5-(trifluoromethyl)-; 2-Bromo-3,5-difluoro-α,α,α-trifluorotoluene
EINECS	Contact for details

Quality Control

Our 2-Bromo-3,5-Difluorobenzodifluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring consistency, traceability, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed to prevent moisture ingress and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (by GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.