Description

Ethyl 2-Bromo-3,6-Difluorobenzoate is a high-purity, multi-functional benzoate ester derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of bromine and fluorine substituents, which enable precise structural modifications and introduce desirable electronic properties into target molecules. This compound is essential for R&D chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring difluorobenzene and aryl bromide motifs.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Material Science Research: Employed in the synthesis of organic electronic materials, such as fluorinated polymers or small molecules for OLEDs.
• Custom Chemical Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects and scale-up processes.
• Academic Research: A valuable reagent for methodological studies in organic chemistry, exploring new fluorination and functionalization reactions.

Basic Information

Product Name	Ethyl 2-Bromo-3,6-Difluorobenzoate
CAS No.	1804408-94-3
Molecular Formula	C9H7BrF2O2
Molecular Weight	265.05 g/mol
Synonyms	2-Bromo-3,6-difluorobenzoic Acid Ethyl Ester; Ethyl 2-Bromo-3,6-difluorobenzoate; Benzoic acid, 2-bromo-3,6-difluoro-, ethyl ester; 3,6-Difluoro-2-bromobenzoic Acid Ethyl Ester; Ethyl 2-Bromo-3,6-difluorobenzoate (CAS 1804408-94-3)
EINECS	Contact for details

Quality Control

Our Ethyl 2-Bromo-3,6-Difluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.