Description

3,3,3-Trifluoro-2,2-Dimethylpropan-1-Amine Hydrochloride is a high-purity, fluorinated amine hydrochloride salt serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of a sterically hindered amine and a trifluoromethyl group, which can significantly alter the physicochemical properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients with enhanced metabolic stability, lipophilicity, and bioavailability. The CAS number for this material is 1803606-63-4.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms and amine functionality contribute to biological activity and environmental persistence.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the creation of fluorinated polymers, coatings, and specialty materials that require specific surface properties, chemical resistance, or optical characteristics.
• Peptide Modification: Useful for introducing fluorinated and sterically hindered motifs into peptides and peptidomimetics to enhance their stability against enzymatic degradation.

Basic Information

Product Name	3,3,3-Trifluoro-2,2-Dimethylpropan-1-Amine Hydrochloride
CAS No.	1803606-63-4
Molecular Formula	C5H11ClF3N
Molecular Weight	177.59 g/mol
Synonyms	1-Amino-3,3,3-trifluoro-2,2-dimethylpropane hydrochloride; 3,3,3-Trifluoro-2,2-dimethyl-1-propanamine hydrochloride; 2,2-Dimethyl-3,3,3-trifluoropropylamine hydrochloride; (3,3,3-Trifluoro-2,2-dimethylpropyl)amine hydrochloride; TFDPA·HCl
EINECS	Contact for details

Quality Control

Every batch of 3,3,3-Trifluoro-2,2-Dimethylpropan-1-Amine Hydrochloride is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure high purity and consistent quality suitable for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.