Description

3-(Trifluoromethyl)Cyclobutan-1-Amine is a specialized fluorinated amine building block of significant interest in advanced organic synthesis. Its unique structure, featuring a cyclobutane ring and a trifluoromethyl group, provides a valuable combination of conformational rigidity and lipophilicity, which is critical for modulating the properties of target molecules. This high-purity intermediate is primarily sought by pharmaceutical and agrochemical research organizations for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Incorporated into advanced polymers and functional materials to impart specific chemical resistance or surface properties.
• Fluorine Chemistry Building Block: Essential for introducing the trifluoromethyl-cyclobutyl motif into complex molecules during exploratory synthetic chemistry.

Basic Information

Product Name	3-(Trifluoromethyl)Cyclobutan-1-Amine
CAS No.	1803601-06-0
Molecular Formula	C5H8F3N
Molecular Weight	139.12 g/mol
Synonyms	3-(Trifluoromethyl)cyclobutanamine; 1-Amino-3-(trifluoromethyl)cyclobutane; 3-(Trifluoromethyl)-1-cyclobutanamine; 3-Trifluoromethylcyclobutan-1-amine; 3-(Trifluoromethyl)cyclobutylamine; Cyclobutanamine, 3-(trifluoromethyl)-; 1803601-06-0
EINECS	Contact for details

Quality Control

Every batch of 3-(Trifluoromethyl)Cyclobutan-1-Amine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high standards required for research and development applications. Our products are supported by comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, which are available upon request. We adhere to relevant industry guidelines to ensure reliable and consistent supply for critical synthetic pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This compound is moisture-sensitive and should be kept under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and degradation. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.