Description

3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethoxy)Benzonitrile is a high-value, multi-functional boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its core value lies in enabling the efficient synthesis of complex molecules through reliable cross-coupling reactions, offering chemists a stable and reactive handle for carbon-carbon bond formation. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who are developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing drug candidates, particularly those containing trifluoromethoxy and benzonitrile motifs which are prevalent in bioactive molecules.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the boronic ester group facilitates the introduction of the aromatic core into complex structures.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials, due to its conjugated system and functional handles.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized to create tagged molecules and bioconjugates for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethoxy)Benzonitrile
CAS No.	1803321-00-7
Molecular Formula	C14H15BF3NO3
Molecular Weight	313.08 g/mol
Synonyms	5-(Trifluoromethoxy)isophthalonitrile-3-boronic acid pinacol ester; 3-Borono-5-(trifluoromethoxy)benzonitrile pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethoxy)benzonitrile; 5-(Trifluoromethoxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; [3-Cyano-5-(trifluoromethoxy)phenyl]boronic acid pinacol ester; PINACOL 3-CYANO-5-(TRIFLUOROMETHOXY)BENZENEBORONATE
EINECS	Contact for details

Quality Control

Our production of 3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethoxy)Benzonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical synthetic steps. Each lot is fully characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We operate under a quality system designed to meet the exacting standards of pharmaceutical R&D and cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maximize shelf-life stability, as boronic esters can be sensitive to prolonged exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.