Description

1,3,2-Dioxaborolane, 2-[3-Methoxy-5-(Trifluoromethoxy)Phenyl]-4,4,5,5-Tetramethyl- is a high-purity, advanced boronic ester derivative designed for sophisticated organic synthesis. This compound is a critical building block in modern pharmaceutical and agrochemical research, enabling the formation of carbon-carbon bonds via cross-coupling reactions. It is primarily utilized by R&D chemists and process development scientists in the life sciences and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing complex biaryl structures found in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require trifluoromethoxy-substituted aromatic systems.
• Material Science Research: Serves as a monomer or functionalization agent in the synthesis of organic electronic materials, such as polymers for OLEDs or OFETs.
• Ligand and Catalyst Development: Employed to create novel boron-containing ligands for transition metal catalysis.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and imaging agents due to its stable boronate ester functionality.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and small-molecule libraries.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-[3-Methoxy-5-(Trifluoromethoxy)Phenyl]-4,4,5,5-Tetramethyl-
CAS No.	1803320-99-1
Molecular Formula	C₁₄H₁₈BF₃O₄
Molecular Weight	318.10 g/mol
Synonyms	2-(3-Methoxy-5-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; [3-Methoxy-5-(trifluoromethoxy)phenyl]boronic acid pinacol ester; 3-Methoxy-5-(trifluoromethoxy)benzeneboronic acid pinacol ester; 5-(Trifluoromethoxy)-3-methoxyphenylboronic acid pinacol ester; (3-Methoxy-5-(trifluoromethoxy)phenyl)boronic acid pinacol ester; PINACOL [3-METHOXY-5-(TRIFLUOROMETHOXY)PHENYL]BORONATE; 1803320-99-1
EINECS	Contact for details

Quality Control

Every batch of our 1,3,2-Dioxaborolane, 2-[3-Methoxy-5-(Trifluoromethoxy)Phenyl]-4,4,5,5-Tetramethyl- is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles via validated methods such as NMR and HPLC.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	≥95.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.