Description

6-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazole is a high-purity, advanced pharmaceutical intermediate featuring a versatile indazole core functionalized with a pinacol boronate ester group. This compound is a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions like the Suzuki-Miyaura reaction for the synthesis of complex, biologically active molecules. It is essential for research and development teams in pharmaceutical, agrochemical, and fine chemical sectors focused on creating novel drug candidates, particularly in oncology and CNS disease areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronate ester group enables efficient carbon-carbon bond formation with aryl/heteroaryl halides, crucial for constructing complex molecular architectures.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Agrochemical Research: Serves as a building block for developing novel pesticides and herbicides.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and target validation.
• Material Science Research: Potential precursor for organic electronic materials and metal-organic frameworks (MOFs).

Basic Information

Product Name	6-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazole
CAS No.	1802433-98-2
Molecular Formula	C₁₃H₁₆BClN₂O₂
Molecular Weight	278.54 g/mol
Synonyms	6-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 6-Chloro-1H-indazole-4-boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-chloro-1H-indazole; 6-Chloro-4-(pinacolboron)-1H-indazole; 6-Chloro-1H-indazole-4-boronic acid, pinacol ester; 1802433-98-2; 6-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole
EINECS	Contact for details

Quality Control

Our 6-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.