Description

2-(5-Fluorofuran-2-Yl)-4,4,5,5-Tetramethyl-1,3,2-dioxaborolane is a high-value organoboron reagent, specifically a fluorinated furan-substituted pinacol boronic ester. This compound is critical for enabling advanced cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern pharmaceutical and agrochemical synthesis. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures with precision.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated heterocyclic motifs to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine atom and furan ring can impart desired biological activity.
• Material Science Research: Serves as a precursor for creating functionalized polymers, liquid crystals, or organic electronic materials through controlled polymerization or conjugation reactions.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a stable, handleable boronic ester partner in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds under mild conditions.
• Chemical Biology & Probe Development: Utilized in the synthesis of fluorescent tags, molecular probes, or bioconjugation agents for diagnostic and research purposes.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale manufacturing of complex organic molecules.

Basic Information

Product Name	2-(5-Fluorofuran-2-Yl)-4,4,5,5-Tetramethyl-1,3,2-dioxaborolane
CAS No.	1799614-84-8
Molecular Formula	C10H14BFO3
Molecular Weight	212.03 g/mol
Synonyms	5-Fluorofuran-2-ylboronic acid pinacol ester; 2-(5-Fluorofuran-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (5-Fluorofuran-2-yl)boronic acid pinacol ester; 5-Fluoro-2-furanylboronic acid pinacol ester; 2-(5-Fluoro-2-furanyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (5-fluorofuran-2-yl)boronate; 5-Fluorofuran-2-yl-Bpin
EINECS	Contact for details

Quality Control

Our production of 2-(5-Fluorofuran-2-Yl)-4,4,5,5-Tetramethyl-1,3,2-dioxaborolane adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.