Description

[2-Chloro-3-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy]Triisopropylsilane is a high-purity, advanced pharmaceutical intermediate and organic synthesis building block. This compound is valued for its dual functionality, combining a protected boronic ester group with a triisopropylsilyl (TIPS) ether, enabling precise cross-coupling reactions and selective deprotection strategies. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronic ester moiety serves as a key coupling partner for the synthesis of biaryl and heterobiaryl structures prevalent in active pharmaceutical ingredients (APIs).
• Protected Intermediate for Medicinal Chemistry: The TIPS-protected phenolic oxygen provides stability during multi-step synthetic sequences, allowing for late-stage deprotection and functionalization.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides that require specific chlorinated biphenyl or phenolic frameworks.
• Liquid Crystal and OLED Material Precursor: Acts as a building block for creating advanced organic electronic materials with tailored steric and electronic properties.
• Polymer Modification: Employed to introduce functional boronate or phenolic handles into polymer backbones for specialty materials.
• Chemical Biology Probes: Useful for synthesizing tagged molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	[2-Chloro-3-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy]Triisopropylsilane
CAS No.	1799612-13-7
Molecular Formula	C22H38BClO3Si
Molecular Weight	424.88 g/mol
Synonyms	2-Chloro-3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy triisopropylsilane; TIPS-Protected Chloromethylphenylboronic Acid Pinacol Ester; Triisopropyl(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)silane; 2-Chloro-3-methyl-4-(TIPS-oxy)phenylboronic acid pinacol ester; 4-[(Triisopropylsilyl)oxy]-2-chloro-3-methylbenzeneboronic acid pinacol ester; B-[4-[(Triisopropylsilyl)oxy]-2-chloro-3-methylphenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of [2-Chloro-3-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy]Triisopropylsilane adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot is characterized by NMR (1H, 13C, 11B), HPLC, and mass spectrometry to confirm identity and high purity (typically >95% by HPLC). Comprehensive Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive (hygroscopic) nature. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.