Description

[2-Methyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzyl]-Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a protected amine and a versatile pinacol boronate ester functional group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern medicinal chemistry and drug discovery. It is primarily utilized by research institutions and pharmaceutical manufacturers for the synthesis of complex, biologically active molecules and novel therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring boronic acid/ester coupling chemistry.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a crucial coupling partner for forming carbon-carbon bonds between aromatic and heteroaromatic systems, a cornerstone of modern organic synthesis.
• Medicinal Chemistry & Drug Discovery: Enables the rapid exploration of chemical space and structure-activity relationships (SAR) in lead optimization programs.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) protecting group allows for selective manipulation of the amine functionality during multi-step synthetic sequences.
• Chemical Biology & Probe Development: Used in the creation of molecular probes and labeled compounds for biological target identification and validation.
• Material Science Research: Potential precursor for the synthesis of organic electronic materials and complex polymers via its reactive functional handles.

Basic Information

Product Name	[2-Methyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzyl]-Carbamic Acid tert-Butyl Ester
CAS No.	1798791-43-1
Molecular Formula	C19H30BNO4
Molecular Weight	347.26 g/mol
Synonyms	N-[(2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl]carbamic acid tert-butyl ester; tert-Butyl N-[[2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]carbamate; 2-Methyl-4-(pinacolboryl)benzyl carbamate Boc-protected; Boc-2-Methyl-4-boronic acid pinacol ester benzylamine; (4-((tert-Butoxycarbonylamino)methyl)-3-methylphenyl)boronic acid pinacol ester; 1798791-43-1; Boc-Protected 2-Methyl-4-Bpin-Benzylamine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for demanding research and pre-clinical development. Each lot is characterized by comprehensive analytical techniques including HPLC, NMR (1H, 13C, 11B), and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool environment. This product is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.