Description

2-Thiopheneacetic Acid, 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Methyl Ester is a high-value organoboron building block, specifically a boronic ester derivative of a thiophene ring system. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs) containing thiophene motifs, used in drug discovery and development.
• Agrochemical Synthesis: Employed in the creation of novel herbicides, fungicides, and insecticides that require specific thiophene-based structures.
• Material Science Research: Used in the development of organic semiconductors, conductive polymers, and liquid crystals for electronic and optoelectronic devices.
• Chemical Biology & Probe Development: Serves as a versatile handle for bioconjugation and the creation of molecular probes for diagnostic and research applications.
• Catalyst & Ligand Development: Acts as a precursor for novel ligands and catalysts used in asymmetric synthesis and other catalytic processes.
• Academic & Contract Research: Essential for methodological research in organic synthesis and for custom synthesis projects in CROs (Contract Research Organizations).

Basic Information

Product Name	2-Thiopheneacetic Acid, 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Methyl Ester
CAS No.	1788894-41-6
Molecular Formula	C13H19BO4S
Molecular Weight	282.16 g/mol
Synonyms	Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-acetate; 2-Thiopheneacetic acid, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; Methyl (5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)acetate; 5-Pinacolatoboryl-2-thiopheneacetic Acid Methyl Ester; 2-(Methoxycarbonylmethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene
EINECS	Contact for details

Quality Control

Our 2-Thiopheneacetic Acid, 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Methyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical characterization, including NMR (¹H, ¹³C, ¹¹B) and HPLC analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, it is recommended to keep the material under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.