Description

Ethyl 6,6-Difluoro-3-Oxo-1,2,5,7-Tetrahydropyrrolizine-8-Carboxylate is a high-purity fluorinated pyrrolizine derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in enabling the efficient construction of complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs). This compound is essential for research and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate its unique difluorinated scaffold into new compounds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory agents.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the difluoro moiety can enhance biological activity and metabolic stability.
• Fluorinated Compound Synthesis: Serves as a versatile precursor for introducing the 6,6-difluoro-3-oxo-pyrrolizine motif into more complex fluorinated molecules for material science and electronics applications.
• Chemical Biology Probes: Employed in the creation of specialized probes and ligands for studying enzyme mechanisms and biological pathways due to its distinctive structural features.
• Process Chemistry & Scale-Up: Supplied in development and commercial quantities to support route scouting, optimization, and cGMP manufacturing of final active substances.

Basic Information

Item	Detail
Product Name	Ethyl 6,6-Difluoro-3-Oxo-1,2,5,7-Tetrahydropyrrolizine-8-Carboxylate
CAS No.	1788873-47-1
Molecular Formula	C11H11F2NO3
Molecular Weight	243.21 g/mol
Synonyms	Ethyl 6,6-difluoro-3-oxo-1,2,5,7-tetrahydro-8H-pyrrolizine-8-carboxylate; 8-Carboethoxy-6,6-difluoro-1,2,5,7-tetrahydro-3H-pyrrolizin-3-one; 6,6-Difluoro-3-oxo-1,2,5,7-tetrahydropyrrolizine-8-carboxylic Acid Ethyl Ester; 8-Ethoxycarbonyl-6,6-difluoro-1,2,5,7-tetrahydro-3H-pyrrolizin-3-one; CAS 1788873-47-1
EINECS	Contact for details

Quality Control

Our Ethyl 6,6-Difluoro-3-Oxo-1,2,5,7-Tetrahydropyrrolizine-8-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.