Description

5-Fluoro-2-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling efficient and selective cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated and heterocyclic compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific pyridine-based structures.
• Material Science Research: Serves as a building block for creating organic electronic materials, ligands for catalysts, and metal-organic frameworks (MOFs).
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group makes it an ideal partner for palladium-catalyzed cross-coupling with aryl or vinyl halides.
• Medicinal Chemistry & Drug Discovery: Enables rapid parallel synthesis and library development for high-throughput screening of new drug candidates.
• Chemical Biology Probes: Used to create tagged molecules for studying biological processes and protein interactions.

Basic Information

Product Name	5-Fluoro-2-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1788062-13-4
Molecular Formula	C₁₂H₁₇BFNO₂
Molecular Weight	237.08 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-fluoro-2-methylpyridine; 5-Fluoro-2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Methyl-5-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-Fluoro-2-picoline-4-boronic acid pinacol ester; (5-Fluoro-2-methylpyridin-4-yl)boronic acid pinacol ester; 4-Borono-5-fluoro-2-methylpyridine pinacol ester; CAS 1788062-13-4
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Assay (NMR)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.