Description

1-(5-Bromo-2-Fluoro-4-Methyl-Phenyl)-Ethanone is a high-purity, synthetically valuable aromatic ketone building block used in advanced organic synthesis. This compound is critical for the development of novel active pharmaceutical ingredients (APIs) and functional materials due to its strategically positioned halogen and fluorine substituents. It is primarily required by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Serves as a building block for developing new herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and advanced polymers where specific halogen-fluorine interactions are desired.
• Chemical Biology Probes: Useful for creating tagged molecules and probes for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific, multi-step synthetic projects.

Basic Information

Product Name	1-(5-Bromo-2-Fluoro-4-Methyl-Phenyl)-Ethanone
CAS No.	1785558-45-3
Molecular Formula	C9H8BrFO
Molecular Weight	231.06 g/mol
Synonyms	5'-Bromo-2'-fluoro-4'-methylacetophenone; 1-(5-Bromo-2-fluoro-4-methylphenyl)ethan-1-one; 2-Fluoro-5-bromo-4-methylacetophenone; 4'-Methyl-5-bromo-2-fluoroacetophenone; 5-Bromo-2-fluoro-4-methylacetophenone; Ethanone, 1-(5-bromo-2-fluoro-4-methylphenyl)-; 1-Acetyl-5-bromo-2-fluoro-4-methylbenzene
EINECS	Contact for details

Quality Control

Our 1-(5-Bromo-2-Fluoro-4-Methyl-Phenyl)-Ethanone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.