Description

3-Amino-1,1-Difluoropropan-2-Ol Hydrochloride is a high-purity, organofluorine building block of significant interest in advanced chemical synthesis. Its value lies in the strategic incorporation of fluorine and amino-alcohol functionalities, which are critical for modulating the biological activity and physicochemical properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in medicinal chemistry programs targeting protease inhibitors, kinase inhibitors, and other bioactive molecules.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and pesticides, where the difluoro motif can enhance metabolic stability and lipophilicity.
• Fluorinated Amino Alcohol Precursor: Serves as a versatile precursor for synthesizing more complex fluorinated amino alcohols and their derivatives, which are valuable chiral auxiliaries and ligands.
• Peptidomimetics Research: Employed in the design and synthesis of fluorinated peptidomimetics to improve peptide stability against enzymatic degradation.
• Material Science: Potential use in the synthesis of specialized fluorinated polymers or surface-modifying agents with unique properties.
• Chemical Biology Probes: Useful for incorporating fluorine atoms into molecular probes for NMR studies or for tracking metabolic pathways.

Basic Information

Item	Detail
Product Name	3-Amino-1,1-Difluoropropan-2-Ol Hydrochloride
CAS No.	1785058-84-5
Molecular Formula	C₃H₈ClF₂NO
Molecular Weight	147.55 g/mol
Synonyms	1,1-Difluoro-3-amino-2-propanol hydrochloride; 3-Amino-1,1-difluoro-2-propanol hydrochloride; 2-Propanol, 3-amino-1,1-difluoro-, hydrochloride; 1,1-Difluoro-3-aminopropan-2-ol HCl; Amino-difluoropropanol hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Amino-1,1-Difluoropropan-2-Ol Hydrochloride is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) documenting all critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.