Description

2-Bromo-5-Cyclopropyl-1H-Imidazole is a high-value, functionalized heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a reactive bromo substituent and a cyclopropyl group, enabling precise molecular construction and diversification. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting kinase inhibition and other biological pathways where the imidazole core is pharmacologically relevant.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the substituted imidazole ring.
• Material Science Research: Serves as a building block for creating novel organic ligands, catalysts, or functional polymers with tailored electronic properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological mechanisms.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Library Synthesis for HTS: A valuable scaffold for generating diverse compound libraries used in high-throughput screening (HTS) campaigns in drug discovery.

Basic Information

Product Name	2-Bromo-5-Cyclopropyl-1H-Imidazole
CAS No.	1783928-66-4
Molecular Formula	C6H7BrN2
Molecular Weight	187.04 g/mol
Synonyms	2-Bromo-5-cyclopropylimidazole; 5-Cyclopropyl-2-bromo-1H-imidazole; 1H-Imidazole, 2-bromo-5-cyclopropyl-; 2-Bromo-5-cyclopropyl-1H-imidazole; 1783928-66-4; 2-Br-5-Cyclopropyl-imidazole
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Cyclopropyl-1H-Imidazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture uptake and degradation. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.