Description

4,4-Difluorotetrahydrofuran-3-Ol is a high-value fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a versatile precursor for introducing fluorine atoms and a functionalized tetrahydrofuran scaffold into complex molecular architectures, enabling the modulation of physicochemical and biological properties. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, as well as by researchers in material science exploring specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of novel fluorinated pesticides and herbicides, where fluorine incorporation can enhance activity and environmental stability.
• Material Science Research: Serves as a monomer or functional modifier in the synthesis of specialty fluoropolymers and advanced organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of fluorinated probes and tags for studying biological mechanisms and diagnostics.
• Catalyst Ligand Development: Acts as a precursor for chiral ligands used in asymmetric catalysis, leveraging its stereogenic center and fluorine atoms.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, particularly in fluorination and ring-forming reactions.

Basic Information

Product Name	4,4-Difluorotetrahydrofuran-3-Ol
CAS No.	1782515-61-0
Molecular Formula	C4H6F2O2
Molecular Weight	124.09 g/mol
Synonyms	3-Hydroxy-4,4-difluorotetrahydrofuran; 4,4-Difluoro-3-hydroxytetrahydrofuran; 4,4-Difluorotetrahydro-3-furanol; 3-Hydroxy-4,4-difluorotetrahydrofuran; 4,4-Difluorooxolan-3-ol; 3-Fluorooxolane-3,4-diol, 4,4-difluoro derivative (IUPAC alternative); 1782515-61-0
EINECS	Contact for details

Quality Control

Every batch of 4,4-Difluorotetrahydrofuran-3-Ol is produced and analyzed under strict quality management protocols to ensure consistency and purity for research and development applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); ensure containers are sealed properly after use to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.