Description

(3,3-Difluorotetrahydro-2H-Pyran-4-Yl)Methanol is a versatile fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its value lies in the strategic incorporation of fluorine atoms and a functionalized pyran ring, which are critical for modulating the physicochemical and biological properties of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the difluorinated moiety can enhance bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis, leveraging its stereogenic center.
• Material Science Research: Employed in the synthesis of fluorinated polymers or specialty chemicals where fluorine content imparts unique properties like oil/water repellency or chemical resistance.
• Fluorine Chemistry Library Building: An essential component for constructing diverse compound libraries in high-throughput screening for drug discovery.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of complex molecules on a commercial scale.

Basic Information

Product Name	(3,3-Difluorotetrahydro-2H-Pyran-4-Yl)Methanol
CAS No.	1782291-14-8
Molecular Formula	C6H10F2O2
Molecular Weight	152.14 g/mol
Synonyms	4-(Hydroxymethyl)-3,3-difluorotetrahydro-2H-pyran; 3,3-Difluorotetrahydro-2H-pyran-4-methanol; (3,3-Difluorotetrahydropyran-4-yl)methanol; 4-(Hydroxymethyl)-3,3-difluorotetrahydropyran; (Tetrahydro-3,3-difluoro-2H-pyran-4-yl)methanol; 3,3-Difluoro-4-hydroxymethyltetrahydropyran
EINECS	Contact for details

Quality Control

Our (3,3-Difluorotetrahydro-2H-Pyran-4-Yl)Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged storage to maintain stability. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.